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Detection of human herpesvirus‐8 DNA in oral ulcer tissues of HIV‐infected individuals
Author(s) -
Alberti L,
Porter SR,
Speight PM,
Scully CM,
Zakrzewska JM,
Williams IG,
Artese L,
Piattelli A,
Ngui SL,
Teo CG
Publication year - 1997
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.1997.tb00345.x
Subject(s) - polymerase chain reaction , sarcoma , human immunodeficiency virus (hiv) , oral mucosa , medicine , nested polymerase chain reaction , biopsy , human herpesvirus , dna , virus , virology , pathology , immunology , dermatology , biology , gene , genetics
OBJECTIVE: To determine the frequency of detection of human herpesvirus‐8 (HHV‐8) in HIV‐related oral ulcers. DESIGN: Analysis of archived biopsy material. METHODS: Nested polymerase chain reaction of DNA extracts. RESULTS: HHV‐8 DNA was detected in six of 10 oral ulcers of HIV‐positive patients without oral Kaposi's sarcoma (KS) lesions and five of 11 oral KS lesions. The positive non‐KS samples were derived from various oral sites. CONCLUSIONS: In HIV‐positive people, HHV‐8 can infect oral tissues that are not affected by KS.