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Cellular immune correlates of clinical severity in oral lichen planus: preliminary association with mood states
Author(s) -
Chiappelli F.,
Kung MA,
Nguyen P.,
Villanueva P.,
Farhadian E Arash,
Eversole LR
Publication year - 1997
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.1997.tb00014.x
Subject(s) - neopterin , oral lichen planus , immune system , flow cytometry , medicine , immunology , lymphocyte , gastroenterology
OBJECTIVES: We investigated cellular immune and psycho‐immune dysfunctions in patients with erosive and non‐erosive oral lichen planus (OLP) lesions. METHODS: Patients with erosive or non‐erosive OLP were screened at the UCLA Dental Clinic. The profile of mood states (POMS) was administered. T lymphocyte subpopulations were monitored by dual fluorescence. T lymphocytes were stimulated with phytohemagglutinin (PHA) for assessment of markers of activation by flow cytometry and of interleukin (IL)‐2 production by ELISA.Plasma cortisol and neopterin levels were assessed by radioimmunoassay. RESULTS: Circulating T cells that express the cluster of differentiation no.4 (CD4 + ) but devoid of the CD45RA marker, and POMS score were significantly associated ( r = 0.83, P < 0.05) in the patients we studied. We found a significantly higher ( P < 0.05) per cent and absolute lymphocyte numbers of circulating CD4+CD45RA cells in the OLP patients with erosive lesions, compared to OLP patients with non‐erosive lesions. The ratio of CD4 + CD45RA + over CD4+CD45RA cells was significantly ( P < 0.05) biased toward the CD4+CD45RA subpopulation in OLP patients with erosive lesions (ratio = 0.19 ± 0.09) compared to patients with non‐erosive OLP lesions (ratio = 0.47 ± 0.15). The expression of CD54, but not that of CD69, was significantly blunted ( P < 0.05) in OLP patients following CD3 + cell stimulation. IL‐2 production and plasma neopterin were normal in these patients. There was no correlation between plasma cortisol and T cell populationS. CONCLUSIONS: We find fine differences in psycho‐immune interactions between patients afflicted with non‐erosive OLP lesions compared to those with erosive OLP lesions.