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Altered interface adhesion molecules in oral lichen planus
Author(s) -
RamirezAmador V,
Dekker NP,
LozadaNur F,
Mirowski GW,
MacPhail LA,
Regezi JA
Publication year - 1996
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.1996.tb00222.x
Subject(s) - basement membrane , laminin , integrin , keratinocyte , extracellular matrix , chemistry , pathology , microbiology and biotechnology , epithelium , connective tissue , cell adhesion molecule , type iv collagen , biology , receptor , medicine , in vitro , biochemistry
OBJECTIVE: To evaluate expression of key epithelial‐connective tissue interface adhesion molecules (basal keratinocyte integrins and extracellular matrix receptors) in oral lichen planus (LP). DESIGN: Integrins α3, α6, β1, β4 and basement membrane proteins laminin 1, laminin 5, collagen IV, and collagen VII were immunohistochemically identified in frozen biopsy specimens (14 oral LP and 11 matched controls) using a standard avidin‐biotin‐peroxidase technique. RESULTS: An increased staining intensity of all antigens in LP was shown, as compared to controls. Integrin expression by LP keratinocytes was generally more intense and appeared on more upper level cells. Staining for basement membrane‐associated extra‐cellular matrix proteins was also generally more intense, although fragmentation and gaps were typically seen. Reactions for α6, β4, laminin 5, and collagen VII stains were particularly intense along the basement membrane. In LP, strands of laminin 5, collagen IV, and collagen VII appeared in the submucosa approximating or duplicating the basement membrane. CONCLUSIONS: The apparent increased expression of the interface‐associated adhesion molecules may be reflective of a keratinocyte compensatory response (due to lymphocyte‐mediated damage) that would functionally help resist epithelial separation (ulceration). Expression of α3β1 and α6β4 would also assist in epithelial migration associated with wound repair. We interpret the submucosal extensions and deposits of basement membrane proteins as representing remnants of basement membrane, indicating recent remodeling or atrophy of epithelial rate ridges.