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Cytokine networks in destructive periodontal disease
Author(s) -
Howells GL
Publication year - 1995
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.1995.tb00192.x
Subject(s) - proinflammatory cytokine , cytokine , receptor , tumor necrosis factor alpha , oncostatin m , immunology , microbiology and biotechnology , biology , autocrine signalling , interleukin 6 , inflammation , biochemistry
BACKGROUND Cytokines are important regulatory proteins, produced by activated cells, which act by binding high affinity cell surface receptors. They are involved in almost all aspects of cell biology and form interacting networks, with cascades of sequential cell activation. They often show overlapping activities ( redundancy ) or the same cytokine may have a variety of different effects (pleiotropy). In excess, certain cytokines are damaging and proinflammatory. Tumour necrosis factor a (TNFα) and interleukin‐I (IL‐I) are markedly proinflammatory, inducing bone resorption, collagenase and prostaglandin E 2 production. OBJECTIVE: This paper focuses on the role of TNFa and IL‐l in the cytokine networks of destructive chronic per‐iodontitis; specifically their regulation by T cell cytokines, receptor antagonists and inhibitory soluble forms of the IL‐l and TNF receptors. CONCLUSION: A hypothesis is proposed that destructive periodontal disease may be due to disregulation of these inhibitors, rather than an overproduction of IL‐l and TNFα per se.