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Rat tissue reaction to MTA FILLAPEX ®
Author(s) -
GomesFilho João Eduardo,
Watanabe Simone,
Lodi Carolina Simonetti,
Cintra Luciano Tavares Angelo,
Nery Mauro Juvenal,
Filho José Arlindo Otoboni,
Dezan Elói,
Bernabé Pedro Felício Estrada
Publication year - 2012
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/j.1600-9657.2011.01096.x
Subject(s) - mineral trioxide aggregate , von kossa stain , chemistry , granulation tissue , dentistry , polyethylene , mineralization (soil science) , connective tissue , biocompatible material , materials science , biomedical engineering , medicine , surgery , pathology , wound healing , biochemistry , alkaline phosphatase , enzyme , organic chemistry , nitrogen
– The aim of this study was to evaluate the rat subcutaneous tissue reaction to implanted polyethylene tubes filled with mineral trioxide aggregate (MTA) FILLAPEX ® compared to the reaction to tubes filled with Sealapex ® or Angelus MTA ® . These materials were placed in polyethylene tubes and implanted into the dorsal connective tissue of Wistar rats for 7, 15, 30, 60, and 90 days. The specimens were stained with hematoxylin and eosin or Von Kossa or left unstained for examination under polarized light. Qualitative and quantitative evaluations of the reaction were performed. All materials caused moderate reactions after 7 days, which decreased with time. The reactions were moderate and similar to that evoked by the control and Sealapex ® on the 15th day. MTA FILLAPEX ® and Angelus MTA caused mild reactions beginning after 15 days. Mineralization and granulation birefringent to polarized light were observed with all materials. It was concluded that MTA FILLAPEX ® was biocompatible and stimulated mineralization.