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Detection of interleukin‐6 in human dental pulp and periapical lesions
Author(s) -
Barkhordar R. A.,
Hayashi C.,
Hussain M. Z.
Publication year - 1999
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/j.1600-9657.1999.tb00744.x
Subject(s) - pulp (tooth) , medicine , dentistry , interleukin 1β , inflammation , interleukin , inflammatory mediator , pulpitis , cytokine , pathology , immunology
— Pulpal and periapical diseases are characterized by inflammation. The cytokine IL‐6 is a major mediator of the host response to tissue injury and infection. This study examined the level of interleukin‐6 (IL‐6) in six inflamed human pulps and six human periapical lesions of endodontic origin using ELISA. Pulp samples from eight clinically impacted teeth were used as controls. The periapical samples exhibited significant levels of IL‐6 (mean= 78.1 ± 9 pg/mg protein) as did inflamed pulpal tissues (mean= 36±3.9 pg/mg protein) compared to healthy pulp (mean= 0.01±0.02 pg/mg protein). These data indicated that IL‐6 was produced and released locally in the inflamed pulpal and periapical lesions.