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Immunohistochemical examination of the distribution of macrophages and CGRP‐immunoreactive nerve fibers in induced rat periapical lesions
Author(s) -
Toriya Y.,
Hashiguchi I.,
Maeda K.
Publication year - 1997
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/j.1600-9657.1997.tb00002.x
Subject(s) - calcitonin gene related peptide , immunohistochemistry , pathology , medicine , calcitonin , nerve fiber , anatomy , neuropeptide , receptor
To clarify the role of calcitonin gene‐related peptide (CGRP) in the development of periapical lesions, we examined the distribution of GGRP‐immunoreactive (IR) nerve fibers and macrophages, and the behavior of bone tissues in experimentally induced rat periapical lesions by immunohistochemical and quantitative methods. Although no extensive changes were observed at 7 days after pulp exposure, CGRP‐IR nerve fibers increased in number until 28 days with a decrease thereafter. These neural changes were closely correlated with the alteration in number of macrophages except on day 7 when macrophages were significantly increased in number as compared with control rats. Tissue repair began to take place and a decrease in number of osteoclasts was observed when the density of CGRP‐IR nerve fibers reached a peak. These results suggested that there might be a close relationship between macrophages and CGRP‐IR nerve fibers and that CGRP‐IR nerve fibers might participate in tissue repair in experimentally induced rat periapical lesions.