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Ciprofloxacin treatment of periapical Pseudomonas aeruginosa infection
Author(s) -
Barnett Frederic,
Axelrod Peter,
Tronstad Leif,
Slots Jorgen,
Graziani Amy,
Talbot George
Publication year - 1988
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/j.1600-9657.1988.tb00311.x
Subject(s) - medicine , ciprofloxacin , metronidazole , periodontitis , pseudomonas aeruginosa , antibiotics , dentistry , pseudomonas infection , microbiology and biotechnology , bacteria , biology , genetics
Survival of bacteria in periapical tissues may be the reason for endodontic failures. This case report describes the treatment of a patient with periapical lesions refractory to endodontic treatment. Microbiological sampling from fistulae associated with the lesions revealed the presence of Pseudomonas aeruginosa. Phenoxymethyl penicillin, metronidazole and carbenicillin were ineffective in eliminating the periapical infection. However, an investigational antibiotic, Ciprofloxacin, which was administered orally twice daily for 15 weeks, proved to be an effective, safe and convenient medicament in the treatment of periapical Pseudomonas aeruginosa infection. The fistulae closed in less than 2 weeks and a radiograph taken during the fourteenth week of therapy showed healing of the apical periodontitis with osseous regeneration. It is suggested that Ciprofloxacin is a valuable agent in the treatment of apical periodontitis, and probably other odontogenic infections caused by susceptible aerobic gram‐negative bacilli.