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Local injection of Benadryl® for the prevention of iatrogenic endodontic flare‐ups
Author(s) -
Nevins Alan,
Friedman Lee,
DeVita Richard,
Schacter William
Publication year - 1988
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/j.1600-9657.1988.tb00302.x
Subject(s) - root canal , debridement (dental) , apical foramen , medicine , pulp (tooth) , dentistry , mast cell , histamine , foramen , surgery , pharmacology , immunology
Endodontic flare‐ups often occur within 24 h of root canal debridement, during which time a small amount of antigen in the form of necrotic pulp tissue and bacteria within the root canal, may be inadvertently extruded through the apical foramen. Subsequently, preformed mediators such as histamine are released into the tissue, causing symptoms of pain and swelling. The IgE‐mast cell mechanism conceivably plays an important role in this development. A rationale for using local injection of Benadryl® prior to canal debridement of infected teeth is given, along with an indication of a lack of adverse reactions and side effects following such treatment.