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Tissue response to a quaternary ammonium compound in a controlled release delivery system
Author(s) -
Barnett Frederic,
Gordon Wanda,
Trope Martin,
Tronstad Leif
Publication year - 1988
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/j.1600-9657.1988.tb00298.x
Subject(s) - ammonium , antiseptic , chemistry , ammonium chloride , eugenol , benzalkonium chloride , nuclear chemistry , delivery system , pharmacology , chromatography , medicine , organic chemistry
The suitability of various antiseptic agents for use in a controlled release delivery system has recently been evaluated for use in endodontic therapy. Of the medicaments tested, a quaternary ammonium compound, dodecyl‐dimethyl benzyl ammonium chloride, was found to be well suited for inclusion in the controlled release preparation. The purpose of this study was to evaluate the tissue response to the quaternary ammonium compound in the controlled release delivery system. For the purpose of comparison, formocresol, Cresatin® and eugenol were included in the study. The tissue‐irritating effect was assessed by incubating muscle tissue that had been in contact with the antiseptics for the demonstration of succinate dehydrogenase activity. Medicaments with a tissue‐irritating effect caused a zone of inhibited enzyme activity in the tissue‐medicament contact areas. The quaternary ammonium compound in the controlled release delivery system was the least irritating of the medicaments tested and caused minimal inhibition of enzyme activity.