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Controlled release of medicaments in endodontic therapy
Author(s) -
Tronstad Leif,
Yang ZuPyn,
Trope Martin,
Barnett Frederic,
Hammond Benjamin
Publication year - 1985
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/j.1600-9657.1985.tb00576.x
Subject(s) - pellets , root canal , ammonium chloride , dentistry , controlled release , ammonium , endodontic therapy , active ingredient , delivery system , chemistry , materials science , medicine , biomedical engineering , composite material , pharmacology , nanotechnology , organic chemistry
It was the purpose of this investigation to study the suitability of a controlled release delivery system for endodontic medicaments, making it possible to maintain a constant concentration of a medicament in the root canal for an extended period of time. The delivery system comprised an inner core matrix containing the medicament surrounded by a polymeric membrane allowing a controlled release of the active ingredient. Controlled release preparations containing formocresol, camphorated paramonochlorphenol, Creation, and a quaternary ammonium compound (dodecyl‐dimethyl‐benzylammonium chloride) were manufactured and applied to root canals of dogs' teeth. In control experiments the same medicaments were applied to root canals by means of cotton pellets. After 1, 3, 7 and 45 clays the pieces of polymeric materials and the cotton pellets were removed from the root canals and tested for antibacterial effect. After 1 d in the root canal none of the medicaments on cotton pellets had an effect. Of the controlled release preparations, the quaternary ammonium compound had a fairly constant effect on bacterial growth for the duration of the experiment (45 d). The results suggested that the idea of improving the effect of endodontic medicaments by means of controlled release delivery systems is valid, and may gain clinical importance in the future.