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Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile
Author(s) -
MoraesVieira P. M. M.,
Bassi E. J.,
Larocca R. A.,
Castoldi A.,
Burghos M.,
Lepique A. P.,
Quintana F. J.,
Araujo R. C.,
Basso A. S.,
Strom T. B.,
Câmara N. O. S.
Publication year - 2013
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2012.04283.x
Subject(s) - leptin , immune system , medicine , adipose tissue , obesity , immunity , hormone , endocrinology , immunology
Leptin, an adipose‐secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lep ob/ob and wild‐type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.