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LITERATURE Watch Implications for transplantation
Author(s) -
FAIRCHILD ROBERT L.,
BROMBERG JONATHAN S.
Publication year - 2012
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2011.03987.x
Subject(s) - cytotoxic t cell , immune system , immunology , innate immune system , pattern recognition receptor , priming (agriculture) , cd8 , inflammation , dendritic cell , antigen presentation , biology , t cell , microbiology and biotechnology , medicine , genetics , germination , botany , in vitro
The innate immune response is mediated through engagement of cellular receptors recognizing conserved molecular patterns of pathogens. This month, Robert Fairchild and Jonathan Bromberg discuss how pattern recognition receptors on dendritic cells influence antigen processing and presentation, and the body's response to inflammation, pointing out that it remains unclear how states of so‐called sterile inflammation evoke signals provoking the priming of T cells.