Premium
Very Early Recurrence of Anti‐Phospholipase A 2 Receptor‐Positive Membranous Nephropathy After Transplantation
Author(s) -
Blosser C. D.,
Ayalon R.,
Nair R.,
Thomas C.,
Beck, Jr. L. H.
Publication year - 2012
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2011.03957.x
Subject(s) - membranous nephropathy , medicine , autoantibody , nephropathy , glomerulonephritis , nephrotic syndrome , kidney transplantation , transplantation , immunology , endocrinology , kidney , antibody , diabetes mellitus
Membranous nephropathy is a common cause of adult nephrotic syndrome, with recent evidence suggesting that 70% of idiopathic disease is associated with anti‐Phospholipase A 2 receptor autoantibodies. We describe a 63‐year‐old man with membranous nephropathy who underwent a kidney transplant and developed recurrent membranous nephropathy with fine granular co‐localization of Phospholipase A 2 receptor and IgG evident on transplant biopsy on day 6 and elevated circulating levels of serum anti‐Phospholipase A 2 receptor autoantibody that declined over time in conjunction with improvement in the serum creatinine and urinary protein. This is a very early case of Phospholipase A 2 receptor‐associated recurrent membranous nephropathy with circulating anti‐Phospholipase A 2 receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.