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LITERATURE Watch Implications for transplantation
Author(s) -
ALEGRE MARIALUISA,
BROMBERG JONATHAN S.
Publication year - 2012
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2011.03937.x
Subject(s) - chronic mucocutaneous candidiasis , medicine , mucocutaneous zone , immunology , immune system , immunity , acquired immune system , disease , pathology
In recent years, insight into the role of unique immune molecules in preventing infections has been gleaned from the study of patients with recurrent single‐agent infections, and the IL‐17 pathway is gaining particular attention. This month, Maria‐Luisa Alegre and Jonathan Bromberg discuss three recent papers that strongly link a defect in the IL‐17 pathway to chronic mucocutaneous candidiasis, a condition thought to be controlled by the adaptive immune system, in contrast to the neutrophil requirement for prevention of invasive candidiasis.