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Early Onset Adenovirus Infection after Simultaneous Kidney–Pancreas Transplant
Author(s) -
Varma M. C.,
Kushner Y. B.,
Ko D. S.,
Kawai T.,
Martins P.,
Kaur P.,
Markmann J. F.,
Kotton C. N.
Publication year - 2011
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2010.03408.x
Subject(s) - medicine , asymptomatic , viremia , thymoglobulin , adenovirus infection , disease , pancreas , immunology , transplantation , kidney transplantation , pathology , virus
Adenoviruses (AdV) are increasingly recognized as important viral pathogens in immunocompromised hosts. The clinical spectrum ranges from asymptomatic viremia to allograft dysfunction, and death. Most of the medical literature is on AdV infection in children and bone marrow transplant recipients. We report a case of AdV in an adult recipient in the first month after simultaneous kidney–pancreas transplant with thymoglobulin induction. This is a rare report of adenovirus infection after multiorgan transplant, and is unique in that it exhibited tissue invasive disease without any localizing signs or allograft dysfunction, while other cases in medical literature had invasive disease of the allograft with allograft dysfunction, failure, or death. In addition, this is the first report of a radiologic presentation of AdV nephritis.