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Long‐Term Follow‐up of a Randomized Trial Comparing Laparoscopic and Mini‐Incision Open Live Donor Nephrectomy
Author(s) -
Dols L. F. C.,
IJzermans J. N. M.,
Wentink N.,
Tran T. C. K.,
Zuidema W. C.,
Dooper I. M.,
Weimar W.,
Kok N. F. M.
Publication year - 2010
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2010.03281.x
Subject(s) - medicine , nephrectomy , surgery , randomized controlled trial , kidney transplantation , renal function , quality of life (healthcare) , kidney , transplantation , urology , nursing
Long‐term physical and psychosocial effects of laparoscopic and open kidney donation are ill defined. We performed long‐term follow‐up of 100 live kidney donors, who had been randomly assigned to mini‐incision open donor nephrectomy (MIDN) or laparoscopic donor nephrectomy (LDN). Data included blood pressure, glomerular filtration rate, quality of life (SF‐36), fatigue (MFI‐20) and graft survival. After median follow‐up of 6 years clinical and laboratory data were available for 47 donors (94%) in both groups; quality of life data for 35 donors (70%) in the MIDN group, and 37 donors (74%) in the LDN group. After 6 years, mean estimated glomerular filtration rates did not significantly differ between MIDN (75 mL/min) and LDN (76 mL/min, p = 0.39). Most dimensions of the SF‐36 and MFI‐20 did not significantly differ between groups at long‐term follow‐up, and most scores had returned to baseline. Twelve percent of the donors reported persistent complaints, but no major complications requiring surgical intervention. Five‐year death‐censored graft survival was 90% for LDN, and 85% for MIDN (p = 0.50). Long‐term outcome of live kidney donation is excellent from the perspective of both the donor and the recipient.