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Mast Cell Degranulation Breaks Peripheral Tolerance
Author(s) -
De Vries V. C.,
Wasiuk A.,
Bennett K. A.,
Benson M. J.,
Elgueta R.,
Waldschmidt T. J.,
Noelle R. J.
Publication year - 2009
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2009.02755.x
Subject(s) - medicine , degranulation , peripheral , mast cell , mast (botany) , peripheral tolerance , immunology , immune tolerance , immune system , receptor
Mast cells (MC) have been shown to mediate regulatory T‐cell (T reg )‐dependent, peripheral allograft tolerance in both skin and cardiac transplants. Furthermore, T reg have been implicated in mitigating IgE‐mediated MC degranulation, establishing a dynamic, reciprocal relationship between MC and T reg in controlling inflammation. In an allograft tolerance model, it is now shown that intragraft or systemic MC degranulation results in the transient loss of T reg suppressor activities with the acute, T‐cell dependent rejection of established, tolerant allografts. Upon degranulation, MC mediators can be found in the skin, T reg rapidly leave the graft, MC accumulate in the regional lymph node and the T reg are impaired in the expression of suppressor molecules. Such a dramatic reversal of T reg function and tissue distribution by MC degranulation underscores how allergy may causes the transient breakdown of peripheral tolerance and episodes of acute T‐cell inflammation.