Premium
Clinical Implications of Advances in the Basic Science of Liver Repair and Regeneration
Author(s) -
Karp S. J.
Publication year - 2009
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2009.02731.x
Subject(s) - medicine , liver regeneration , regeneration (biology) , liver transplantation , liver disease , cholangiocyte , disease , liver failure , intensive care medicine , bioinformatics , hepatocyte , transplantation , pathology , surgery , biology , microbiology and biotechnology , biochemistry , in vitro
Recent advances in our understanding of the basic mechanisms that control liver regeneration and repair will produce the next generation of therapies for human liver disease. Insights gained from large‐scale genetic analysis are producing a new framework within which to plan interventions. Identification of specific molecules that drive regeneration will increase the options for live‐donor liver transplantation, and help treat patients with small‐for‐size syndrome or large tumors who would otherwise have inadequate residual mass after resection. In a complementary fashion, breakthroughs in the ability to manipulate various cell types to adopt the hepatocyte or cholangiocyte phenotype promise to revolutionize therapy for acute liver failure and metabolic liver disease. Finally, elucidating the complex interactions of liver cells with each other and various matrix components during the response to injury is essential for fabricating a liver replacement device. This focused review will discuss how a variety of important scientific advances are likely to impact the treatment of specific types of liver disease.