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Human FOXP3+ Regulatory T Cells in Transplantation
Author(s) -
Boros P.,
Bromberg J. S.
Publication year - 2009
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2009.02704.x
Subject(s) - foxp3 , immunosuppression , transplantation , il 2 receptor , treg cell , immunology , medicine , regulatory t cell , immune system , phenotype , function (biology) , microbiology and biotechnology , biology , t cell , genetics , gene
CD4+CD25+FOXP3+ suppressive regulatory T cells (Treg) represent a subset of immune regulatory cells. Based on experimental results, Treg have recently been considered as a potential treatment option in several diseases. Compared with murine Treg, human CD4+CD25+FOXP3+ cells are less well characterized and understood, so a thorough understanding of their biology is vital before clinical applications can be initiated. This review summarizes knowledge on generation, phenotypic characteristics and function of human Treg. The possible role of these cells in organ transplantation, as well as interactions between immunosuppression and Treg are also discussed.