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Fate of the Mate: The Influence of Delayed Graft Function in Renal Transplantation on the Mate Recipient
Author(s) -
Johnson J. F.,
Jevnikar A. M.,
Mahon J. L.,
Muirhead N.,
House A. A.
Publication year - 2009
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2009.02692.x
Subject(s) - medicine , renal function , urology , retrospective cohort study , transplantation , cohort , kidney transplantation , kidney , multivariate analysis , single center , surgery
Delayed graft function (DGF) in a deceased‐donor renal recipient is associated with allograft dysfunction 1‐year posttransplant. There is limited research about the influence to allograft function on the mate of a DGF recipient over time. Using a retrospective cohort design, we studied 55 recipients from a single center. The primary outcome was the change in glomerular filtration rate (GFR) 1‐year posttransplant. The secondary outcome was the GFR at baseline. We found that mates to DGF recipients had a mean change in GFR 1‐year posttransplant of −11.2 mL/min, while the control group had a mean change of −0.4 mL/min. The difference in the primary outcome was significant (p = 0.025) in a multivariate analysis, adjusting for cold ischemic time, panel reactive antibody level, allograft loss, human leukocyte antibody (HLA)‐B mismatches and HLA‐DR mismatches. No significant difference between groups was found in baseline GFR. In conclusion, mates to DGF recipients had a significantly larger decline in allograft function 1‐year posttransplant compared to controls with similar renal function at baseline. We believe strategies that may preserve allograft function in these ‘ at‐risk ’ recipients should be developed and tested.