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Progression of Organ Failure in Patients Approaching Brain Stem Death
Author(s) -
Lytle F. T.,
Afessa B.,
Keegan M. T.
Publication year - 2009
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2009.02575.x
Subject(s) - medicine , interquartile range , sofa score , intensive care , organ transplantation , organ dysfunction , declaration , retrospective cohort study , helsinki declaration , declaration of helsinki , intensive care unit , transplantation , intensive care medicine , informed consent , sepsis , pathology , alternative medicine , political science , law
We performed a retrospective cohort study to document the progression of organ dysfunction in 182 critically ill adult patients who subsequently met criteria for brain stem death (BSD). Patients were admitted to intensive care units (ICUs) of Mayo Medical Center, Rochester, MN, between January 1996 and December 2006. Daily sequential organ failure assessment (SOFA) scores were used to assess the degree of organ dysfunction. Serial SOFA scores were analyzed using analysis of variance (ANOVA). Mean (standard deviation, SD) SOFA score on the first ICU day was 8.9 (3.2). SOFA scores did not significantly change over the course of ICU stay. 67.6% of patients donated one or more organs after BSD was declared. The median time from ICU admission to declaration of BSD was 18.8 h (interquartile range 10.3–45.0), and in those who donated organs, the time from declaration of BSD to organ retrieval was 11.8 h (9.5–17.6). The fact that mean SOFA scores did not change significantly over time, even after BSD occurred, has implications for the timing of retrieval of organs for transplantation.