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Managing Cancer Risk and Decision Making After Kidney Transplantation
Author(s) -
Webster A. C.,
Wong G.,
Craig J. C.,
Chapman J. R.
Publication year - 2008
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2008.02385.x
Subject(s) - medicine , intensive care medicine , kidney transplantation , malignancy , cancer , dialysis , disease , transplantation , kidney disease , risk assessment , population , diabetes mellitus , environmental health , computer security , computer science , endocrinology
Kidney transplant recipients are at higher risk of cancer at most sites, and cancer after transplantation causes considerable morbidity and mortality. To optimize long‐term patient outcomes, clinicians balance the prospect of graft failure and dialysis, with competing risks of diabetes, cardiovascular and cerebrovascular disease and the risk of malignancy. In this paper we critically examine the assumptions underpinning primary prevention, immunization, chemoprevention and screening programs, and highlight considerations when applying evidence to the kidney transplant population, and suggest a clinical research agenda that aims to define a rational approach to managing posttransplant cancer risk.