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The Roles of CD8 Central and Effector Memory T‐Cell Subsets in Allograft Rejection
Author(s) -
Oberbarnscheidt M. H.,
Ng YH.,
Chalasani G.
Publication year - 2008
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2008.02335.x
Subject(s) - homing (biology) , cd8 , cytotoxic t cell , immunology , effector , immune system , t cell , lymphatic system , biology , medicine , in vitro , genetics , ecology
The contribution of secondary lymphoid tissue‐homing central memory T cells (T CM ) and peripheral tissue‐homing effector memory T cells (T EM ) to allograft rejection is not known. We tested whether T EM is the principal subset responsible for allograft rejection due to the nonlymphoid location of target antigens. Skin allograft rejection was studied after transferring either CD8 T CM or T EM to wild‐type mice and to mice that lack secondary lymphoid tissues. We found that CD8 T CM and T EM were equally effective at rejecting allografts in wild‐type hosts. However, CD8 T EM were significantly better than T CM at rejecting allografts in the absence of secondary lymphoid tissues. CD8 T CM were dependent upon secondary lymphoid tissues more than T EM for optimal differentiation into effectors that migrate into the allograft. Recall of either CD8 T CM or T EM led to accumulation of T EM after allograft rejection. These findings indicate that either CD8 T CM or T EM mediate allograft rejection but T EM have an advantage over T CM in immune surveillance of peripheral tissues, including transplanted organs.