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Respiratory Failure Associated with Human Metapneumovirus Infection in an Infant Posthepatic Transplant
Author(s) -
Evashuk K. M. A.,
Forgie S. E.,
Gilmour S.,
Huynh H.,
Lee B. E.,
Robinson J. L.
Publication year - 2008
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2008.02278.x
Subject(s) - medicine , extracorporeal membrane oxygenation , human metapneumovirus , respiratory distress , methylprednisolone , respiratory failure , respiratory system , liver transplantation , mechanical ventilation , intubation , transplantation , surgery , respiratory tract infections
This is the first reported case of respiratory failure associated with human metapneumovirus (hMPV) infection in a liver transplant recipient or in a pediatric solid transplant recipient. A 9‐month‐old female developed respiratory distress 8 days following a liver transplant. hMPV was detected and she required intubation followed by extracorporeal membrane oxygenation for 26 days. Immunosuppressive medications were stopped during the acute infection except for methylprednisolone as treatment for acute respiratory distress. Serial Doppler ultrasounds were used to monitor for hepatic vessel thromboses and serum liver function tests to assess for hepatic dysfunction and there was no evidence of allograft rejection. The patient recovered from the nosocomial hMPV infection with satisfactory pulmonary function and possible mild developmental delay.