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A Closer Look at T Cells in the Artery Wall
Author(s) -
Rose M. L.
Publication year - 2008
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2008.02206.x
Subject(s) - medicine , immune system , coronary artery disease , population , disease , chemokine , pathology , phenotype , immunology , biology , biochemistry , environmental health , gene
A recent analysis of T cells in the arterial wall of cardiac transplant recipients with graft vasculopathy demonstrates effector memory CD4+ T cells, some of which bear the senescent CD28 null phenotype. This observation begs the question whether chronically activated CD4+ T cells may be directly damaging to the vessel wall. See also article by Hagemeijer et al in this issue on page 1040.