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Cellulitis Revealing a Cryptococcosis‐Related Immune Reconstitution Inflammatory Syndrome in a Renal Allograft Recipient
Author(s) -
Lanternier F.,
Chandesris M.O.,
Poirée S.,
Bougnoux M.E.,
Mechai F.,
MamzerBruneel M.F.,
Viard J.P.,
GalmicheRolland L.,
Lecuit M.,
Lortholary O.
Publication year - 2007
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2007.01994.x
Subject(s) - medicine , immune reconstitution inflammatory syndrome , cryptococcosis , context (archaeology) , cryptococcus neoformans , cellulitis , immunology , immune system , human immunodeficiency virus (hiv) , microbiology and biotechnology , biology , paleontology , viral load , antiretroviral therapy
Immune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients. We report here the case of a renal transplant recipient who developed severe cellulitis in the context of Cryptococcus neoformans ‐associated IRIS while undergoing reduction of his immunosuppressive therapy. IRIS appeared concomitantly with a dramatic increase of blood CD4+ T cells (94–460/mm 3 ) and required the administration of a short‐term steroid therapy to resolve.