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Evidence of Immune Tolerance to Blood Group Antigens in a Case of ABO‐Incompatible Pediatric Liver Transplantation
Author(s) -
Ohdan H.,
Zhou W.,
Tanaka Y.,
Irei T.,
Fuchimoto Y.,
Egawa H.,
Asahara T.
Publication year - 2007
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2007.01901.x
Subject(s) - abo blood group system , medicine , peripheral blood mononuclear cell , immunology , antigen , antibody , liver transplantation , immune system , transplantation , blood type (non human) , immune tolerance , biology , in vitro , biochemistry
In a 12‐year‐old patient with blood group O, who had received a partial liver graft 10 years ago from his father with blood group A, the levels of anti‐A‐specific antibodies (Abs) were persistently undetectable after the transplantation, while the levels of anti‐B‐specific Abs gradually increased and attained a plateau. Peripheral blood mononuclear cells (PBMCs) from this patient were engrafted into NOD/SCID mouse in order to investigate the immune response to donor‐type blood group antigens. Even after sensitization with blood group‐A erythrocytes, no anti‐A Abs were detected in the serum samples of the mouse that received PBMCs from the blood group‐O recipient of group‐A liver allograft, however, immunoglobulins specific for antigens other than the A antigens were produced. Thus, we provide a possible evidence of immune tolerance to blood group antigens in this ABO‐incompatible pediatric liver transplantation.