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Anemia Is Associated with Mortality in Kidney‐Transplanted Patients—A Prospective Cohort Study
Author(s) -
Molnar M. Z.,
Czira M.,
Ambrus C.,
Szeifert L.,
Szentkiralyi A.,
Beko G.,
Rosivall L.,
Remport A.,
Novak M.,
Mucsi I.
Publication year - 2007
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2006.01727.x
Subject(s) - medicine , prospective cohort study , anemia , cohort study , cohort , kidney transplantation , intensive care medicine , kidney
Although anemia is a known risk factor of mortality in several patient populations, no prospective study to date has demonstrated association between anemia and mortality in kidney‐transplanted patients. In our prospective cohort study (TransQol‐HU Study), we tested the hypothesis that anemia is associated with mortality and graft failure (return to dialysis) in transplanted patients. Data from 938 transplanted patients, followed at a single outpatient transplant center, were analyzed. Sociodemographic parameters, laboratory data, medical history and information on comorbi‐dity were collected at baseline. Data on 4‐year outcome (graft failure, mortality or combination of both) were collected prospectively from the patients' charts. Both mortality and graft failure rate during the 4‐year follow‐up was significantly higher in patients who were anemic at baseline (for anemic vs nonanemic patients, respectively: mortality 18% vs. 10%; p < 0.001; graft failure 17% vs 6%; p < 0.001). In multivariate Cox proportional hazard models the presence of anemia significantly predicted mortality (HR = 1.690; 95% CI: 1.115–2.560) and also graft failure (HR = 2.465; 95% CI: 1.485–4.090) after adjustment for several covariables. Anemia, which is a treatable complication, is signi‐ficantly and independently associated with mortality and graft failure in kidney‐transplanted patients.