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Epstein‐Barr Virus: Evasive Maneuvers in the Development of PTLD
Author(s) -
Snow Andrew L.,
Martinez Olivia M.
Publication year - 2007
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2006.01650.x
Subject(s) - medicine , malignancy , virus , epstein–barr virus , lymphoproliferative disease , immunology , immune system , disease , b cell , lymphoma , lymphoproliferative disorders , virology , epstein–barr virus infection , antibody , pathology
Epstein‐Barr virus (EBV) infection is linked to ∼90% of B‐cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B‐cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV‐associated malignancies.