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Evaluation of Islet Transplantation from Non‐Heart Beating Donors
Author(s) -
Noguchi H.,
Iwanaga Y.,
Okitsu T.,
Nagata H.,
Yonekawa Y.,
Matsumoto S.
Publication year - 2006
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2006.01499.x
Subject(s) - medicine , islet , transplantation , c peptide , insulin , autoantibody , heart transplantation , diabetes mellitus , gastroenterology , endocrinology , immunology , antibody
We evaluated islet transplantation from non‐heart beating donors (NHBDs) with our Kyoto Islet Isolation Method. All patients had positive C‐peptide after transplantation. The average HbA 1C levels of the five recipients significantly improved from 7.8 ± 0.4% at transplant to 5.2 ± 0.2% currently (p < 0.01). Three patients with no or a single autoantibody became insulin independent while the other two patients with double autoantibodies reduced their insulin requirement but did not become insulin independent. C‐peptide in patients who became insulin‐independent gradually increased after each transplantation whereas C‐peptide in patients who did not become insulin‐independent from 3 months after the first transplantation to the next transplantation dramatically decreased. The β‐score of the three patients who became insulin independent was the best of eight. In conclusion, our method makes it feasible to use NHBDs for islet transplant into type 1 diabetic patients efficiently.