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BKV Replication and Cellular Immune Responses in Renal Transplant Recipients
Author(s) -
Binggeli S.,
Egli A.,
Dickenmann M.,
Binet I.,
Steiger J.,
Hirsch H. H.
Publication year - 2006
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2006.01460.x
Subject(s) - elispot , immunology , medicine , bk virus , cd8 , t cell , immune system , peripheral blood mononuclear cell , virology , human leukocyte antigen , antigen , transplantation , kidney transplantation , biology , biochemistry , in vitro
Hammer and colleagues report on BKV-specific T-cell responses in peripheral blood mononuclear cells (PBMC) of 15 viremic kidney transplant recipients (1). After stimulation with overlapping peptides spanning the viral capsid protein VP1, interferon-c (IFNc )-producing CD4+ T cells were observed in 7 patients (47%), including 2 patients (13%) with a CD8+ T-cell response. All patients with a detectable T-cell response had plasma BKV loads of >250 000 copies (c)/mL. Both patients with VP1-specific CD8+ T cells were the only ones to lose their grafts during follow-up. The authors concluded that high BKV load of >250 000 c/mL correlated with peripheral BKV-specific T-cell responses and that BKV-specific CD8+ responses indicated a risk for subsequent allograft loss (1).