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Soluble HLA‐G Expression and Renal Graft Acceptance
Author(s) -
Qiu J.,
Terasaki P. I.,
Miller J.,
Mizutani K.,
Cai J.,
Carosella E. D.
Publication year - 2006
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2006.01417.x
Subject(s) - medicine , human leukocyte antigen , antibody , immunology , hla g , antigen
HLA‐G is a potentially interesting molecule associated with immunosuppressive function. We survey here the presence of soluble HLA‐G (sHLA‐G) in serial serum samples of renal transplants. A total of 330 sera of from 65 patients were tested for sHLA‐G with ELISA. IgG/IgM antibodies to HLA, and MICA antibodies were also previously tested. After serial analysis of the 65 patients' 330 sera, 50% of 26 patients in functioning group had consistent sHLA‐G expression or became positive, in comparison to 20.5% among 39 patients who rejected their transplants (p = 0.013). Thus sHLA‐G was associated with functioning transplants. Eighty percent (77 of 96) of the HLA IgG positive sera had no sHLA‐G expression, while 81.4% (83 of 102) of the HLA‐G(+) sera had no HLA IgG (p = 0.005), which showed a negative association between sHLA‐G and the presence of HLA IgG antibodies (which was previously been shown to be associated with failure). In this preliminary survey, sHLA‐G was found in the serum of about 30% of renal transplant patients. sHLA‐G had a negative association with allograft failure from chronic rejection, and a negative relationship with the production of HLA IgG antibodies. The significance of sHLA‐G in renal transplants remains to be determined.