z-logo
Premium
Urine NGAL and IL‐18 are Predictive Biomarkers for Delayed Graft Function Following Kidney Transplantation
Author(s) -
Parikh C. R.,
Jani A.,
Mishra J.,
Ma Q.,
Kelly C.,
Barasch J.,
Edelstein C. L.,
Devarajan P.
Publication year - 2006
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2006.01352.x
Subject(s) - medicine , urine , urology , creatinine , lipocalin , urinary system , kidney transplantation , dialysis , transplantation , renal function , receiver operating characteristic , kidney
Delayed graft function (DGF) due to tubule cell injury frequently complicates deceased donor kidney transplants. We tested whether urinary neutrophil gelatinase‐associated lipocalin (NGAL) and interleukin‐18 (IL‐18) represent early biomarkers for DGF (defined as dialysis requirement within the first week after transplantation). Urine samples collected on day 0 from recipients of living donor kidneys (n = 23), deceased donor kidneys with prompt graft function (n = 20) and deceased donor kidneys with DGF (n = 10) were analyzed in a double blind fashion by ELISA for NGAL and IL‐18. In patients with DGF, peak postoperative serum creatinine requiring dialysis typically occurred 2–4 days after transplant. Urine NGAL and IL‐18 values were significantly different in the three groups on day 0, with maximally elevated levels noted in the DGF group (p < 0.0001). The receiver–operating characteristic curve for prediction of DGF based on urine NGAL or IL‐18 at day 0 showed an area under the curve of 0.9 for both biomarkers. By multivariate analysis, both urine NGAL and IL‐18 on day 0 predicted the trend in serum creatinine in the posttransplant period after adjusting for effects of age, gender, race, urine output and cold ischemia time (p < 0.01). Our results indicate that urine NGAL and IL‐18 represent early, predictive biomarkers of DGF.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here