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Signaling T‐Cell Survival and Death by IL‐2 and IL‐15
Author(s) -
Zambricki Elizabeth,
Shigeoka Alana,
Kishimoto Hidehiro,
Sprent Jon,
Burakoff Steven,
Carpenter Charles,
Milford Edgar,
McKay Dianne
Publication year - 2005
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2005.01075.x
Subject(s) - cytokine , apoptosis , signal transduction , receptor , interleukin 15 , medicine , microbiology and biotechnology , alpha chain , cytokine receptor , programmed cell death , pi3k/akt/mtor pathway , interleukin , cancer research , immunology , biology , biochemistry
Interleukin 2 (IL‐2) and interleukin 15 (IL‐15) bind to common T‐cell surface receptors comprised of unique alpha (IL‐2Rα or IL‐15Rα) and shared β/γ chain subunits. Ligation of this receptor by IL‐2 can lead to apoptosis whereas IL‐15 ligation favors cell survival. Our study examined intra‐cellular signaling events associated with IL‐2‐ and IL‐15‐induced apoptosis and survival in human T cells. We found IL‐2 and IL‐15 could both induce apoptosis and survival; the outcome depended on cytokine concentration. No qualitative differences in Jak/Stat, Ras/MAPK or PI3K/AKT signaling were seen over a wide range of IL‐2 and IL‐15 concentrations. These findings suggest that, like T‐cell receptor signaling, IL‐2R β/γ chain signaling is regulated, or “tuned,” by the concentration of cytokine.