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Transplantation and 6‐Month Follow‐up of Renal Transplantation from a Donor with Systemic Lupus Erythematosus and Lupus Nephritis
Author(s) -
Schwartzman Michael S.,
Zhang Ping L.,
Potdar Santosh,
Malek Sayeed K.,
Norfolk Evan R.,
Hartle J. Edward,
Weicker Cristen A.,
Yahya Taher M.,
Shaw John H.
Publication year - 2005
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2005.00922.x
Subject(s) - medicine , lupus nephritis , transplantation , biopsy , renal biopsy , glomerulonephritis , renal function , renal pathology , systemic lupus erythematosus , kidney transplantation , nephritis , disease , kidney , pathology
Transplantation of kidneys with pre‐existing glomerulonephritis (GN) has rarely been reported. Little is known of the subsequent evolution of donor pathology in the recipient. We report a transplant using a donor with systemic lupus erythematosus (SLE) and a history of remote acute renal failure but normal renal function at death. Although the screening harvest biopsy was unremarkable, time zero post‐implantation renal biopsy showed evidence of lupus nephritis (LN). Sequential protocol biopsies demonstrated gradual resolution of the donor pathology, and renal function was stable despite severe cardiac disease in the recipient. Studies examining the role of functional and biopsy data on outcomes in expanded criteria renal transplantation are reviewed, and the limits of guidance from use of this data are discussed. Pre‐existing mild GN may not be an absolute donor exclusion for candidates willing to accept expanded criteria donors. Use of expanded pool kidneys should be guided by functional, biopsy and demographic information, as no single factor alone predicts outcome.