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Is It Right to Promote Living Donor Liver Transplantation for Fulminant Hepatic Failure in Pediatric Recipients?
Author(s) -
Reding Raymond
Publication year - 2005
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2005.00915.x
Subject(s) - medicine , fulminant hepatic failure , fulminant , donation , context (archaeology) , intensive care medicine , organ donation , liver transplantation , united network for organ sharing , transplantation , quality of life (healthcare) , surgery , nursing , paleontology , biology , economics , economic growth
Good clinical results are currently achieved in elective pediatric liver transplantation (LT) with living‐related donors. However, the question whether such therapeutic approach may also be promoted in case of fulminant hepatic failure (FHF) remains a matter of debate. This work briefly reviews the ethical background and overall medical results of living‐related donation in pediatric LT. When considering FHF, success is essentially conditioned by the availability of a suitable organ donor before the onset of irreversible brain damage and death of the transplant candidate on the waiting list. Accordingly, living donor LT provides several advantages for patients with FHF, including the short waiting time and the access to a transplant with reduced ischemic injury and optimal graft quality; however, living donation is also characterized by several drawbacks to be carefully considered, particularly the possibility of coercion to the recipient's family as well as the operative risks of the emergency donor hepatectomy. The ethical soundness of living parental donor LT for FHF is discussed, with emphasis to the type of medical context, with or without access to an efficient emergency postmortem organ sharing system.