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Reversibility of ‘Secondary Hypercalcitoninemia’ After Kidney Transplantation
Author(s) -
Borchhardt Kyra A.,
Hörl Walter H.,
SunderPlassmann Gere
Publication year - 2005
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2005.00908.x
Subject(s) - medicine , transplantation , kidney transplantation , pentagastrin , urology , kidney disease , kidney , creatinine , endocrinology , calcitonin , renal function , basal (medicine) , gastroenterology , stomach , gastric acid , insulin
Whether the increase of calcitonin (CT) concentration in patients with chronic kidney disease (CKD) is reversible or not after kidney transplantation is not known. We examined the effect of kidney transplantation on basal and pentagastrin‐stimulated CT in CKD patients with elevated screening CT levels.Before transplantation, the median basal CT concentration of 17 patients was 31 pg/mL (13–76), and decreased to 8 pg/mL (4–28) at 23 months (2–34) after kidney transplantation (p < 0.00005). The maximum concentration of pentagastrin‐stimulated CT was 63 pg/mL (25–110) before transplantation and decreased to 20 pg/mL (8–91) (p < 0.00005) thereafter. There was a linear association between CT and calcium as well as between phosphorus and parathyroid hormone at the time of screening. After transplantation, CT correlated with serum creatinine.Therefore, the increase of CT concentration in patients with impaired kidney function presumably reflects ‘secondary hypercalcitoninemia’ due to C‐cell hyperactivity.