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Broncho‐alveolar Lavage Matrix Metalloproteases as a Sensitive Measure of Bronchiolitis Obliterans
Author(s) -
Taghavi Shahrokh,
Krenn Katharina,
Jaksch Peter,
Klepetko Walter,
Aharinejad Seyedhossein
Publication year - 2005
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2005.00865.x
Subject(s) - bronchiolitis obliterans , medicine , lung transplantation , matrix metalloproteinase , gastroenterology , bronchoalveolar lavage , lung , transplantation , bronchiolitis , immunology , pathology , respiratory system
Bronchiolitis obliterans (BO) is a survival‐limiting factor in lung transplantation. There are no common BO markers in use. Since BO is associated with extracellular matrix remodeling, we asked whether matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs) could serve as BO markers. In 72 lung transplant patients (34 BO syndrome (BOS) 0, 15 BOS 0‐p, and 23 BOS 1) serum and broncho‐alveolar lavage (BAL) MMP and TIMP levels were examined by ELISA. The BAL cell counts were additionally analyzed. The serum MMP‐2, MMP‐8, MMP‐9 and TIMP‐2 levels were not different in all groups. In contrast, the BAL MMP‐8, ‐9 and TIMP‐1 levels were significantly elevated in BOS 0‐p (p = 0.003; p = 0.007; p = 0.0003, respectively) and BOS 1 (p = 0.003; p = 0.001; p = 0.0004, respectively) as compared to BOS 0 patients. The BAL MMP‐8, ‐9 and TIMP‐1 levels were significant predictors of BOS 0‐p (p = 0.01; p = 0.01; p = 0.01, respectively) and BOS‐1 (p = 0.007; p = 0.01; p = 0.006, respectively) in receiver operating characteristic analysis. Except for BAL macrophages that were significantly decreased in BOS 0‐p versus BOS 0 patients; other cell counts were not different between the groups. BAL MMP‐8, ‐9 and TIMP‐1 might be useful markers to detect BO in lung transplant patients.