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Development of Diabetes Mellitus Following Kidney Transplantation: A Canadian Experience
Author(s) -
Gourishankar Sita,
Jhangri Gian S.,
Tonelli Marcello,
Wales Loreen H.,
Cockfield Sandra M.
Publication year - 2004
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2004.00591.x
Subject(s) - medicine , tacrolimus , calcineurin , diabetes mellitus , kidney transplantation , transplantation , population , trough level , cumulative incidence , incidence (geometry) , surgery , gastroenterology , endocrinology , environmental health , physics , optics
The onset of diabetes mellitus following kidney transplantation or post‐transplant diabetes mellitus (PTDM) is now recognized as being an increasingly common complication that is associated with poor graft and patient survival. The incidence and clinical correlates of PTDM in a Canadian kidney transplant population has not been examined and may vary based on differences in demographics (i.e. race). Furthermore, little information exists on the association of variables such as cmulative dose of corticosteroids and trough calcineurin inhibitor levels and PTDM. We examined all recipients of a kidney transplant in our center between 1995 and 2001 and found an overall PTDM rate of 9.8%. Five clinical factors were independently associated with PTDM: older recipient age, deceased donor, hepatitis C antibody status, rejection episode and use of tacrolimus (vs. cyclosporine). Furthermore, cmulative corticosteroid dose and calcineurin inhibitor trough level were not associated with PTDM. This study demonstrates that in a Canadian kidney transplant population that there is a significant risk of PTDM following kidney transplantation, and it is therefore advisable to minimize this risk.

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