Premium
Relevance of IL10, TGFβ1, TNFα, and IL4Rα Gene Polymorphisms in Kidney Transplantation: A Collaborative Transplant Study Report
Author(s) -
Mytilineos Joannis,
Laux Gunter,
Opelz Gerhard
Publication year - 2004
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2004.00561.x
Subject(s) - medicine , relevance (law) , transplantation , kidney transplantation , interleukin 10 , transforming growth factor , immunology , cytokine , political science , law
Single nucleotide polymorphisms (SNPs) of cytokine genes have been shown to influence cytokine plasma levels. Cytokines are important mediators during organ graft rejection. It was reported that certain cytokine genotypes are associated with improved kidney graft survival.In the present study, SNPs within the IL10 promoter gene, the first exon of the TGFβ1 gene, the TNFα promoter gene, and the IL4Rα gene were analyzed in 2298 first and 1901 repeat cadaver kidney recipients. We found no significant effect on the survival rate of first grafts. Among retransplants, we observed that recipients who were homozygous for the high TNFα producer genotype −308 A had a significantly lower graft survival rate than patients who were carriers of the low producer genotype −308 G (at 3 years: 63.0% vs. 79.5%; p corrected = 0.0116). The results of this large‐scale study suggest that IL10, TGFβ1, TNFα, and IL4Rα cytokine genotypes do not affect the survival of primary kidney grafts. The outcome of retransplants appears to be affected by TNFα genotypes only.