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Severe Hepatitis C Infection in a Renal Transplant Recipient Following Hepatitis C Genotype Mismatch Transplant
Author(s) -
Schussler Thomas,
StaffeldCoit Catherine,
Eason James,
Nair Satheesh
Publication year - 2004
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2004.00504.x
Subject(s) - medicine , immunosuppression , genotype , tacrolimus , transplantation , hepatitis , hepatitis c , organ transplantation , kidney transplantation , immunology , renal transplant , gastroenterology , biology , biochemistry , gene
We report a case of a 32‐year‐old female with histologically and clinically inactive chronic hepatic C infection, who received a cadaveric renal transplant from a hepatitis C‐positive donor with a different genotype. The genotype mismatch (genotype 1 to genotype 2) and change to tacrolimus‐based immunosuppression resulted in severe hepatitis C infection characterized by a 10‐fold increase in transaminase levels and grade 3 inflammation histologically. Our report highlights the risk of genotype‐mismatch transplants in solid organ transplantation.