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Statins in Solid Organ Transplantation: Is There an Immunosuppressive Effect?
Author(s) -
Kobashigawa Jon A.
Publication year - 2004
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2004.00475.x
Subject(s) - medicine , atorvastatin , tacrolimus , transplantation , hyperlipidemia , fluvastatin , organ transplantation , kidney disease , kidney , kidney transplantation , heart transplantation , immunology , diabetes mellitus , endocrinology , simvastatin
Cardiac allograft vasculopathy is one of the major causes of mortality late after heart transplantation. This disease process occurs to a lesser extent in patients with other donor organs; however, a long‐term graft dysfunction is similarly described in kidney, liver and lung transplant recipients. There are multiple immune and nonimmune risk factors associated with this vasculopathic disease process, one of which includes hyperlipidemia. Use of lipid lowering agents, specifically HMG‐CoA reductase inhibitors (statins) was initially reported to have possible immunosuppressive effects in a single center study of heart transplant recipients. This has not been observed in kidney transplant recipients; however, a large randomized trial demonstrated a significant cardiovascular risk reduction in fluvastatin‐treated kidney transplant patients, outcome similar to the numerous nontransplant clinical trials of statins in atherosclerosis. In two recent in vitro studies, statins have been reported to repress induction of MHC‐II by interferon‐gamma and selectively block leukocyte function antigen‐1, both of which decrease T‐lymphocyte activation. In conclusion, statins appear to have outcome benefits in heart and kidney transplant patients; however, firm evidence for a clinical immunosuppressive effect is lacking. Further studies in humans will be needed to demonstrate this potential effect of statins. Overall, the outcome benefits of statins from the heart and kidney clinical studies provide a firm rationale to support the use of statins in organ transplantation.