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Sirolimus‐Induced Angioedema
Author(s) -
Wadei Hani,
Gruber Scott A.,
ElAmm Jose M.,
Garnick James,
West Miguel S.,
Granger Darla K.,
Sillix Dale H.,
Migdal Stephen D.,
Haririan Abdolreza
Publication year - 2004
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2004.00429.x
Subject(s) - medicine , discontinuation , sirolimus , adverse effect , mycophenolate , angioedema , mycophenolic acid , broad spectrum , dermatology , surgery , transplantation , gastroenterology , pharmacology , chemistry , combinatorial chemistry
Sirolimus (SRL) is a macrolide immunosuppressant that has gained widespread use in organ transplantation. Its full spectrum of side‐effects is yet to be defined. We describe herein three cases of SRL‐induced angioedema (AE) in African‐American (AA) primary renal allograft recipients who received SRL in combination with mycophenolate mofetil and steroids. In two cases, AE manifested after SRL was restarted after a period of discontinuation. The third case presented upon initial exposure to the drug. None of the patients was receiving any drug that has been previously associated with AE. Complete resolution occurred only after SRL was withdrawn. AE has not recurred in any of the patients during a follow‐up period of up to 21 months. We conclude that AE is a previously unrecognized adverse event associated with SRL use. Close monitoring for this side‐effect, especially in AA patients, is warranted.