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Fusion of approaches to the treatment of organ failure
Author(s) -
Ogle Brenda,
Cascalho Marilia,
Platt Jeffrey L.
Publication year - 2004
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6135.2004.0347.x
Subject(s) - xenotransplantation , medicine , organ transplantation , transplantation , organ system , lung transplantation , bioinformatics , computational biology , intensive care medicine , pathology , biology , surgery , disease
Because organ transplantation is the preferred treatment for organ failure, the demand for human organs for transplantation is large and growing. From this demand, several fields based on new technologies for the replacement or repair of damaged tissues and organs have emerged. These fields include stem cell biology, cloning, tissue engineering and xenotransplantation. Here we evaluate the potential contribution of these to the devising of alternative approaches to organ replacement. We present our vision for the development of two structurally complex organs – the lung and the kidney – based on a ‘fusion’ of new and established technologies.