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Activin A and its Regulatory Molecules in Placenta and Fetal Membranes of Women with Preterm Premature Rupture of the Membranes Associated with Acute Chorioamnionitis
Author(s) -
Torricelli Michela,
Voltolini Chiara,
Novembri Romina,
Bocchi Caterina,
Di Tommaso Mariarosaria,
Severi Filiberto M.,
Petraglia Felice
Publication year - 2012
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2012.01180.x
Subject(s) - follistatin , chorioamnionitis , placenta , premature rupture of membranes , medicine , fetus , fetal membrane , andrology , messenger rna , pregnancy , endocrinology , biology , gene , biochemistry , genetics
Labeled Problem To investigate regulation of activin A and related molecules in placenta/fetal membranes from preterm premature rupture of membranes ( pPROM ) associated with acute chorioamnionitis ( ACA ). Method of Study Tissues were obtained from women with spontaneous preterm deliveries ( PTD ), pPROM without ACA , pPROM with ACA . Activin A , follistatin, and nodal and cripto mRNA were measured by RT ‐ PCR . Results Activin A mRNA was up‐regulated in tissues from pPROM , in presence or absence of HCA , respect to PTD and in pPROM with ACA respect to pPROM without ACA . Follistatin mRNA expression did not differ between the groups. In placenta, nodal mRNA showed the same trend of activin A , while cripto was down‐regulated in pPROM with ACA than other groups. Nodal and cripto were not expressed by fetal membranes. Conclusion The study shows the involvement of activin A pathway in pPROM with ACA . Further studies will focus on its role in placental immune functions.