Premium
An Analysis of C ‐Reactive Protein, Procalcitonin, and D ‐Dimer in Pre‐Eclamptic Patients
Author(s) -
Kucukgoz Gulec Umran,
Tuncay Ozgunen Fatma,
Baris Guzel Ahmet,
Buyukkurt Selim,
Seydaoglu Gulsah,
Ferhat Urunsak Ibrahim,
Cuneyt Evruke Ismail
Publication year - 2012
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2012.01171.x
Subject(s) - procalcitonin , eclampsia , d dimer , c reactive protein , medicine , gastroenterology , pregnancy , inflammation , sepsis , biology , genetics
Problem The aim of this study was to evaluate serum procalcitonin (PCT), C‐reactive protein (CRP), and plasma D‐Dimer levels in mild and severe pre‐eclampsia. Method of study Serum PCT, CRP, and D‐Dimer levels were analyzed in 64 cases with pre‐eclampsia as the study group and 33 healthy pregnant women in the third trimester as the control group. Pre‐eclamptic group consisted of mild ( n = 31) and severe pre‐eclamptic subgroup ( n = 33). Laboratory results were compared between the groups and diagnostic usefulness of these parameters were evaluated. Results PCT, CRP, and D‐Dimer levels were significantly higher in study group than the control group ( P = 0.001). PCT, CRP, and D‐Dimer were significantly higher in the patients with severe pre‐eclampsia than mild pre‐eclampsia. There were significant positive correlations between these markers and mean arterial pressure (MAP). Logistic regression analysis using the control and pre‐eclampsia group showed that higher PCT (OR, 15.68; 95%‐CI, 3.15–78.10), CRP (OR, 14.29; 95%‐CI, 3.08–66.34), and D‐Dimer levels (OR, 4.97; 95%‐CI, 1.22–20.29) were found to be risk factors significantly associated with pre‐eclampsia. Conclusions This study results confirm that evidence of a possible exaggerated systemic inflammatory response in pre‐eclampsia especially in severe pre‐eclampsia.