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Differential Expression of CXC Chemokines CXCL 10 and CXCL 12 in Term and Pre‐term Neonates and Their Mothers
Author(s) -
Aminzadeh Fariba,
Ghorashi Zohreh,
Nabati Saeedeh,
Ghasemshirazi Mohsen,
Arababadi Mohammad Kazemi,
Shamsizadeh Ali,
Karimabad Mojgan Noroozi,
Khorramdelazad Hossein,
Darakhshan Shokoofeh,
Hassanshahi Gholamhossein
Publication year - 2012
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2012.01167.x
Subject(s) - chemokine , cord blood , immunology , fetus , medicine , full term , inflammation , andrology , biology , pregnancy , genetics
Background and Aim Pre‐term delivery is a mostly unknown frequent disorder worldwide. This project aimed to investigate the circulating levels of CXCL 12 ( SDF ‐1) and CXCL 10 ( IP ‐10) in cord blood of term and pre‐term delivered fetuses and their corresponding mothers. Material and Methods Cord and peripheral blood samples were collected from 50 pre‐term and 50 term infants and their mothers. Serum levels of CXCL 12 and CXCL 10 were measured by ELISA . Results The findings of this study indicated that the circulating levels of CXCL 10 were elevated in mothers bearing pre‐term infants, while CXCL 12 was only increased in pre‐term infants. Conclusion The results suggested that the pathophysiological status of both mother and infant are involved in prematurity. Moreover, these findings suggest an inflammatory response in pre‐term labor, which probably is controlled by inducible chemokines such as CXCL 10.