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Cyclooxygenase‐2 ( COX ‐2 ) Gene‐765G/C Polymorphism and Advanced‐Stage Endometriosis in Korean Women
Author(s) -
Kim Hye Yeon,
Cho SiHyun,
Choi Young Sik,
Yang Hyo In,
Lee Kyung Eun,
Seo Seok Kyo,
Lee Byung Seok
Publication year - 2012
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2012.01151.x
Subject(s) - endometriosis , genotype , allele , medicine , stage (stratigraphy) , gastroenterology , cyclooxygenase , allele frequency , gynecology , oncology , gene , biology , genetics , enzyme , paleontology , biochemistry
Problem We investigated the association of COX ‐2 gene‐765G/C polymorphism and risk of advanced‐stage endometriosis in K orean women. Method of study This study consisted of 268 women with advanced‐stage endometriosis and 242 control women without endometriosis in K orea. Subjects were genotyped for the ‐765 G / C polymorphism of the COX ‐2 gene by RFLP ‐ PCR analysis. Results There were significant differences in the genotype distributions of the ‐765 G / C polymorphism between patients with advanced‐stage endometriosis and control subjects. The C allele for ‐765 G / C was associated with significantly lower risk of advanced‐stage endometriosis ( OR , 0.14; 95% CI , 0.06–0.30). Conclusions We have demonstrated a significant genetic association between the ‐765 G / C polymorphism and advanced‐stage endometriosis in K orean women. The ‐765 C allele may be protective against the development of the disease in Korean women.