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Serum sTREM ‐1 (Soluble Triggering Receptor Expressed on Myeloid Cells‐1) Associates Negatively with Embryo Quality in Infertility Patients
Author(s) -
HallerKikkatalo Kadri,
Sarapik Aili,
Faure Gilbert C.,
Béné MarieChristine,
Massin Frédéric,
Salumets Andres,
Uibo Raivo
Publication year - 2012
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2011.01102.x
Subject(s) - follicular fluid , follicular phase , embryo quality , medicine , infertility , myeloid , andrology , biomarker , endocrinology , receptor , biology , immunology , embryo , in vitro fertilisation , pregnancy , oocyte , biochemistry , genetics , microbiology and biotechnology
Problem Soluble triggering receptor expressed on myeloid cells‐1 ( sTREM ‐1) is a useful biomarker of infection and inflammation. Method of study We studied serum and follicular fluid sTREM ‐1 in infertile patients ( N = 110) utilizing enzyme‐linked immunosorbent assay. Results Serum and follicular sTREM ‐1 were in good correlation (Pearson's correlation 0.56, P < 0.0001) with higher values in follicular fluid (140.4 ± 34.4 and 115.6 ± 35.1 pg/ mL , t ‐test, P < 0.0001). Endometriosis associated with lower follicular and serum sTREM ‐1 compared with male factor infertility patients (age‐adjusted r = −25.7 pg/ mL , P = 0.018; r = −22.1 pg/ mL , P = 0.030). No associations between follicular or serum sTREM ‐1 and clinical parameters were found, except higher serum sTREM ‐1 associated with lower embryo quality in all patients (adjusted r = −0.3%, P = 0.033), with a cutoff value between 111.5 and 113.3 pg/ mL (OR = 0.38, P = 0.048; OR = 0.34, P = 0.028) predicting that more than 39% of embryos would be with good quality. Conclusion Serum sTREM ‐1 could represent a prognostic marker for female fecundity, probably indicating impaired inflammatory reaction of immune system.